Neutron-activated ¹⁵³Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy.
Identifieur interne : 001259 ( Main/Exploration ); précédent : 001258; suivant : 001260Neutron-activated ¹⁵³Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy.
Auteurs : RBID : pubmed:21934547English descriptors
- KwdEn :
- Gastric Mucosa, Gastrointestinal Tract (radionuclide imaging), Gastrointestinal Transit, Humans, Indium Radioisotopes (diagnostic use), Ion Exchange Resins (chemical synthesis), Ion Exchange Resins (diagnostic use), Neutrons, Radioisotopes (diagnostic use), Radiopharmaceuticals (chemical synthesis), Radiopharmaceuticals (diagnostic use), Samarium (diagnostic use).
- MESH :
- chemical , chemical synthesis : Ion Exchange Resins, Radiopharmaceuticals.
- chemical , diagnostic use : Indium Radioisotopes, Ion Exchange Resins, Radioisotopes, Radiopharmaceuticals, Samarium.
- radionuclide imaging : Gastrointestinal Tract.
- Gastric Mucosa, Gastrointestinal Transit, Humans, Neutrons.
Abstract
Nuclear medicine techniques are well established for the investigation of gastrointestinal (GI) motility and transit. Ion-exchange resins radiolabelled with ⁹⁹mTc and ¹¹¹In are widely used as nonabsorbable radiopharmaceutical markers, with ¹¹¹In being preferred for whole-gut transit studies. This radionuclide, however, is not produced in many countries and may be expensive when obtained through international shipment. This study describes the use of neutron-activated ¹⁵³Sm-resin as an alternative tracer for use in GI scintigraphic investigation. A measure of 50 mg of stable samarium-152 chloride (¹⁵²SmCl₃) was incorporated into 100 mg of cation-exchange resin and irradiated in a neutron flux of 1 × 10¹³ cm⁻² s⁻¹ for 100 s to achieve an activity of 5 MBq after 66 h. Aliquots of ¹¹¹In-radiolabelled resin (5 MBq) were prepared for comparison of labelling and stability. Radiolabelling efficiencies were obtained by washing resin with distilled water, and the activity lost was measured. The radiolabelled resins were immersed in simulated gastric and intestinal fluid environments, and the retention of ¹⁵³Sm³⁺ and ¹¹¹In³⁺ was measured over a 24 h period. At 66 h after production, 91.15 ± 12.42% of ¹⁵³Sm was bound to the resin after washing in distilled water, whereas radiolabelling with ¹¹¹In achieved 99.96 ± 0.02% efficiency. Both radiolabelled resins demonstrated almost 100% stability in simulated intestinal fluid and >90% stability in artificial gastric juice over 24 h. The performance of neutron-activated ¹⁵³Sm-resin is similar to that of ¹¹¹In-resin and can be used as an alternative tracer for GI transit studies when In is not available.
DOI: 10.1097/MNM.0b013e32834b3ac8
PubMed: 21934547
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neutron-activated ¹⁵³Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy.</title><author><name sortKey="Yeong, Chai Hong" uniqKey="Yeong C">Chai-Hong Yeong</name><affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea></affiliation></author><author><name sortKey="Abdullah, Basri Johan Jeet" uniqKey="Abdullah B">Basri Johan Jeet Abdullah</name></author><author><name sortKey="Ng, Kwan Hoong" uniqKey="Ng K">Kwan-Hoong Ng</name></author><author><name sortKey="Chung, Lip Yong" uniqKey="Chung L">Lip-Yong Chung</name></author><author><name sortKey="Goh, Khean Lee" uniqKey="Goh K">Khean-Lee Goh</name></author><author><name sortKey="Sarji, Sazilah Ahmad" uniqKey="Sarji S">Sazilah Ahmad Sarji</name></author><author><name sortKey="Perkins, Alan Christopher" uniqKey="Perkins A">Alan Christopher Perkins</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1097/MNM.0b013e32834b3ac8</idno><idno type="RBID">pubmed:21934547</idno><idno type="pmid">21934547</idno><idno type="wicri:Area/Main/Corpus">001146</idno><idno type="wicri:Area/Main/Curation">001146</idno><idno type="wicri:Area/Main/Exploration">001259</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gastric Mucosa</term><term>Gastrointestinal Tract (radionuclide imaging)</term><term>Gastrointestinal Transit</term><term>Humans</term><term>Indium Radioisotopes (diagnostic use)</term><term>Ion Exchange Resins (chemical synthesis)</term><term>Ion Exchange Resins (diagnostic use)</term><term>Neutrons</term><term>Radioisotopes (diagnostic use)</term><term>Radiopharmaceuticals (chemical synthesis)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Samarium (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Ion Exchange Resins</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Ion Exchange Resins</term><term>Radioisotopes</term><term>Radiopharmaceuticals</term><term>Samarium</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Gastrointestinal Tract</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gastric Mucosa</term><term>Gastrointestinal Transit</term><term>Humans</term><term>Neutrons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nuclear medicine techniques are well established for the investigation of gastrointestinal (GI) motility and transit. Ion-exchange resins radiolabelled with ⁹⁹mTc and ¹¹¹In are widely used as nonabsorbable radiopharmaceutical markers, with ¹¹¹In being preferred for whole-gut transit studies. This radionuclide, however, is not produced in many countries and may be expensive when obtained through international shipment. This study describes the use of neutron-activated ¹⁵³Sm-resin as an alternative tracer for use in GI scintigraphic investigation. A measure of 50 mg of stable samarium-152 chloride (¹⁵²SmCl₃) was incorporated into 100 mg of cation-exchange resin and irradiated in a neutron flux of 1 × 10¹³ cm⁻² s⁻¹ for 100 s to achieve an activity of 5 MBq after 66 h. Aliquots of ¹¹¹In-radiolabelled resin (5 MBq) were prepared for comparison of labelling and stability. Radiolabelling efficiencies were obtained by washing resin with distilled water, and the activity lost was measured. The radiolabelled resins were immersed in simulated gastric and intestinal fluid environments, and the retention of ¹⁵³Sm³⁺ and ¹¹¹In³⁺ was measured over a 24 h period. At 66 h after production, 91.15 ± 12.42% of ¹⁵³Sm was bound to the resin after washing in distilled water, whereas radiolabelling with ¹¹¹In achieved 99.96 ± 0.02% efficiency. Both radiolabelled resins demonstrated almost 100% stability in simulated intestinal fluid and >90% stability in artificial gastric juice over 24 h. The performance of neutron-activated ¹⁵³Sm-resin is similar to that of ¹¹¹In-resin and can be used as an alternative tracer for GI transit studies when In is not available.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21934547</PMID><DateCreated><Year>2011</Year><Month>11</Month><Day>02</Day></DateCreated><DateCompleted><Year>2012</Year><Month>03</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5628</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>12</Issue><PubDate><Year>2011</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Nuclear medicine communications</Title><ISOAbbreviation>Nucl Med Commun</ISOAbbreviation></Journal><ArticleTitle>Neutron-activated ¹⁵³Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy.</ArticleTitle><Pagination><MedlinePgn>1256-60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MNM.0b013e32834b3ac8</ELocationID><Abstract><AbstractText>Nuclear medicine techniques are well established for the investigation of gastrointestinal (GI) motility and transit. Ion-exchange resins radiolabelled with ⁹⁹mTc and ¹¹¹In are widely used as nonabsorbable radiopharmaceutical markers, with ¹¹¹In being preferred for whole-gut transit studies. This radionuclide, however, is not produced in many countries and may be expensive when obtained through international shipment. This study describes the use of neutron-activated ¹⁵³Sm-resin as an alternative tracer for use in GI scintigraphic investigation. A measure of 50 mg of stable samarium-152 chloride (¹⁵²SmCl₃) was incorporated into 100 mg of cation-exchange resin and irradiated in a neutron flux of 1 × 10¹³ cm⁻² s⁻¹ for 100 s to achieve an activity of 5 MBq after 66 h. Aliquots of ¹¹¹In-radiolabelled resin (5 MBq) were prepared for comparison of labelling and stability. Radiolabelling efficiencies were obtained by washing resin with distilled water, and the activity lost was measured. The radiolabelled resins were immersed in simulated gastric and intestinal fluid environments, and the retention of ¹⁵³Sm³⁺ and ¹¹¹In³⁺ was measured over a 24 h period. At 66 h after production, 91.15 ± 12.42% of ¹⁵³Sm was bound to the resin after washing in distilled water, whereas radiolabelling with ¹¹¹In achieved 99.96 ± 0.02% efficiency. Both radiolabelled resins demonstrated almost 100% stability in simulated intestinal fluid and >90% stability in artificial gastric juice over 24 h. The performance of neutron-activated ¹⁵³Sm-resin is similar to that of ¹¹¹In-resin and can be used as an alternative tracer for GI transit studies when In is not available.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yeong</LastName><ForeName>Chai-Hong</ForeName><Initials>CH</Initials><Affiliation>University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></Author><Author ValidYN="Y"><LastName>Abdullah</LastName><ForeName>Basri Johan Jeet</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Kwan-Hoong</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Lip-Yong</ForeName><Initials>LY</Initials></Author><Author ValidYN="Y"><LastName>Goh</LastName><ForeName>Khean-Lee</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Sarji</LastName><ForeName>Sazilah Ahmad</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Perkins</LastName><ForeName>Alan Christopher</ForeName><Initials>AC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucl Med Commun</MedlineTA><NlmUniqueID>8201017</NlmUniqueID><ISSNLinking>0143-3636</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Ion Exchange Resins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>42OD65L39F</RegistryNumber><NameOfSubstance>Samarium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Gastric Mucosa</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gastrointestinal Tract</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gastrointestinal Transit</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Ion Exchange Resins</DescriptorName><QualifierName MajorTopicYN="N">chemical synthesis</QualifierName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neutrons</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">chemical synthesis</QualifierName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Samarium</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1097/MNM.0b013e32834b3ac8</ArticleId><ArticleId IdType="pubmed">21934547</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001259 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001259 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:21934547
|texte= Neutron-activated ¹⁵³Sm-ion-exchange resin as a tracer for gastrointestinal scintigraphy.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21934547" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |